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In Vivo Toxicology Service (Mouse, Rat) Download Altogen Labs PowerPoint Presentation: [] Preclinical in vivo toxicology is the study of toxic effects of chemical substances based on statistical and quantitative analysis. At Altogen Labs, toxicology studies can include acute, subchronic and chronic toxicity tests. Acute toxicology studies focus on the toxicological effects following a single large dose of the substance of interest. For longer-term studies subchronic and chronic studies are done to simulate long-term use of the drugs and their subsequent adverse effects. Subchronic toxicology studies include repeated small dosages of the test substance over a period of time up to 90 days.